A Solid-Phase Route to 18F-Labeled Tracers, Exemplified by the Synthesis of [18F]2-Fluoro-2-deoxy-D-glucose
Scintillating synthesis: 18F-Containing radiopharmaceuticals can be prepared by using [18F]fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM=ethoxymethyl). The method has allowed the synthesis of the widely used imaging agent [18F]fluoro-2-deoxy-D-glucose in good radiochemical yield and with high chemical purity.
Solid_phase [18F]FDG에 관한 논문이 Angewandte Volume 46, Issue 6, p 941-944에 실렸네요. 참고하세요.